PROTEIN MINIMA FOR MAINTENANCE
نویسندگان
چکیده
منابع مشابه
Local Minima-Based Exploration for O -Lattice Protein Folding
Proteins have speci c native folding structures, but without proper folding, these proteins function incorrectly and lead to disease. The major challenge lies in e ectively predicting such native conformations. We present a new and simple algorithmic approach to help predict protein structures from amino acid sequences based on energy minimization. In the search for the minimal energy conformat...
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We present a new and simple algorithmic approach to help predict protein structures from amino acid sequences based on energy minimization. In the search for the minimal energy conformation, we analyze and exploit the protein structures found at the various local minima to direct the search the global minimum. As such, we explore the energy landscape efficiently by considering only the space of...
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EVOLVING LOCAL MINIMA IN THE PROTEIN ENERGY SURFACE Brian S Olson, PhD George Mason University, 2013 Dissertation Director: Dr. Amarda Shehu Proteins are the molecular tools of living cells and the path to unraveling their function is through modeling and understanding their structure. Many diseases occur when a protein loses its intended function due to inability to form the appropriate struct...
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Protein folding is a very difficult global optimization problem. Furthermore it is coupled with the difficult task of designing a reliable force field with which one has to search for the global minimum. A summary of a series of optimization methods developed and applied to various problems involving polypeptide chains is described in this paper. With recent developments, a computational treatm...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1915
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)87643-8